ABSTRACT
The discovery of immune checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an important role in the development of cancer immunotherapy. However, immune-related adverse events often occur because of the enhanced immune response enabled by these agents. Antibiotics are widely applied in clinical treatment, and they are inevitably used in combination with immune checkpoint inhibitors. Clinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpoint inhibitors. Studies have shown that the gut microbiota is essential for the interaction between immune checkpoint inhibitors and antibiotics, although the exact mechanisms remain unclear. This review focuses on the interactions between immune checkpoint inhibitors and antibiotics, with an in-depth discussion about the mechanisms and therapeutic potential of modulating gut microbiota, as well as other new combination strategies.
Subject(s)
Humans , Anti-Bacterial Agents/therapeutic use , Immune Checkpoint Inhibitors/therapeutic use , Immunotherapy , Neoplasms/drug therapy , Programmed Cell Death 1 ReceptorABSTRACT
Objective To discuss the application effect of new physical therapy technique in the rehabilitation of patients with hand injury afte operation. Methods Patients with hand injury after operation (150 cases) were divided into the observation group (87 cases) and the control group (63 cases) randomly. The control group received routine treatment and nursing. The observation group was given irradiation by He-Ne laser therapeutic instrument, vinegar therapy and static electromagnetic field therapy. The rehabilitative effect after operation was compared between the two groups. Results The time for disappearance of pain and swelling in the obsevation group was shorter than that of the control group (P<0.05). Conclusions Application of new physical therapy technique in patients with hand injury afte operation could shorten time of rehabilitation and improve rehabilitative quality.